Liver Transplant News Home » Organ Donation News Survival Rate Improved by Living Donor Liver Transplantation by Sheela Philomena on September 29, 2011 at 2:10 PM Organ Donation News
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Survival Rate Improved by Living Donor Liver Transplantation Related Links Medindia on - Liver Transplantation The liver is the largest organ in the human body and is situated below the diaphragm, on the right side of the abdomen.
Read More... For More Information Quiz on Liver ORGAN DONATION - Slide Show Liver Transplantation for Bile Duct Cancer Liver transplantation candidates without hepatocellular carcinoma (HCC) have a greater survival benefit from a living liver transplant than waiting for a deceased donor liver transplant, shows study. The study now available in the October issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases, reports that survival benefit from LDLT remains significant across the range of model for end-stage liver disease (MELD) scores, but this benefit was not apparent for low MELD candidates with HCC.
Liver diseases such as hepatitis B and C, nonalcoholic fatty liver disease, and HCC can range in severity from mild to life-threatening liver failure. In end-stage liver disease, when patient life is at risk, transplantation is the recommended option. According to the Organ Procurement and Transplant Network (OPTN), as of September 2011 more than 16,000 Americans are on the waiting list to receive a liver. Between January and June 2011 OPTN reported 3108 liver transplants were performed in the U.S., with roughly 96% being DDLTs and 4% LDLTs.
Previous studies found receipt of LDLT to be associated with improved survival compared with waiting for DDLT, however it remains unclear whether this advantage persists in candidates with low MELD scores (less than 15). "In order to better inform liver transplant candidates of survival outcomes, our study investigated the mortality risk of undergoing transplantation using livers from living donors versus waiting to receive a deceased donor organ," explains lead author Carl Berg, M.D., with the University of Virginia Health System.