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Help a disabled artist, writer & activist access their home and community while beating a genetic mutation that causes cancer.

Karrie is an award-winning writer, Intermedia artist, fabric designer, ink-maker, and outspoken disability activist in need of a wheelchair van, home mods, physical therapy, medical imaging due to Chiari-Syringomyelia & EDS, as well as preventive surgeries such as a hysterectomy & screenings due to a genetic mutation in MSH6 called Lynch Syndrome or DNA Mismatch Repair Deficiency or HNPCC that puts them at extremely high risk of various cancers, especially colon, uterine, ovarian, stomach, esophageal, bladder, pancreatic, brain, skin, and liver.

Updates (28)

January 1, 2023

Happy new year, friends, family, and lovely strangers out there! Thank you for your support through a very difficult 2022! 2023 is shaping up with some new health challenges related to all my conditions, but I feel hopeful knowing my community has continued to lend support. Thank you, thank you! I will post an update soon, after I see oncology, orthopedics, and neurology again! I hope you are keeping warm and safe & I will "see" you soon!

February 4, 2022

Thank you so much for all the support! I wanted to write a quick update. Some of you have seen me posting about this. I recently was found to have the pathogenic gene that runs in my family and has caused numerous cancers. The diagnosis is Lynch Syndrome and it results in an extremely elevated risk of several cancers: colon, brain, endometrial, ovarian, skin, stomach, pancreas, bladder and more. All of these cancers are prevalent in my family history and I have had my own bouts with cancer.

This gene, MSH6, typically is responsible for PROTECTING us from cancer by repairing mistakes in transcription. Unfortunately, with my mutation, it does the opposite and causes cancer. This happens even with good preventive strategies like avoiding red meat, not smoking, etc. It is, as my doctors say, a ticking time bomb.

I will require numerous annual screenings + preventive surgeries + chemopreventive medications + travel for studies (I am currently trying to get into several studies, including a vaccine trial that uses the neoantigens produced by Lynch tumors as a target -- training the immune system too attack these cancers and delay onset + increase positive treatment outcomes since our cancers tend to resist typical treatments).

These surgeries are not covered under my plan (or even most plans) but would reduce my risk of SOME of these cancers by 90%. The screenings will also be a huge financial issue because our deductible is so high and many are not covered as "preventive" medicine.

This is in addition to the already high costs for my disabilities, the disaster damage we are still trying to repair, home mods, and DME (including a wheelchair van). To say we are drowning would be an understatement.

My very first scan post-Lynch diagnosis found a mass and I already am facing these costs.

Donations are tax deductible (check your particular tax situation, of course) and no funds are released without proof of expense.

Photo Galleries (6)

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Guestbook

January 24, 2023

<3

Juan J

November 30, 2022

xoxox

Gayle Brandeis

November 30, 2022

Thinking of you on #GivingTuesday.

Yvette Renee