In March 2005, Missy had surgery to remove a GIST tumor in her abdomen. During this extensive surgery, oxygen and blood supply were cut off from her small bowel which in turn caused it to die. Because of this, Missy was placed on a transplant list as it was the only way for her survival.
In July 2005, Missy was granted her first multi-visceral transplant. The first three weeks, things progressed beyond what was expected. Then, Missy started going into severe rejection. She went thru a couple of months of constant treatment and it was eventually decided to give her a second multi-visceral transplant, this time, including a liver as hers had overworked itself with the first transplant.